FGF8在诱导,启动和维持小四肢发育中的作用
P H Crossley1, G Minowada, C A MacArthur
1Department of Anatomy, School of Medicine, University of California, San Francisco 94143-0452, USA.
Cell
|January 12, 1996
概括
纤维细胞生长因子8 (FGF8) 是小四肢形成的关键诱导因子. FGF8通过调节基因表达和中皮外生长来启动和维持四肢芽的发育.
科学领域:
- 发育生物学 发展生物学
- 分子生物学分子生物学
- 胚胎学 胚胎学
背景情况:
- 纤维细胞生长因子8 (FGF8) 与胚胎发育有关.
- FGF8在启动和维持四肢形成中的确切作用需要进一步阐明.
研究的目的:
- 调查FGF8作为子四肢发育的内源诱导剂的作用.
- 确定FGF8表达和胚胎脏分化之间的联系.
- 了解FGF8如何调节肢体形成期间的基因表达和中皮外生.
主要方法:
- 在胚胎中分析FGF8的表达.
- 研究FGF8对外皮和中皮的影响.
- 分析索尼克刺的表情模式.
主要成果:
- 介质中皮层中的FGF8表达与胚胎脏分化有关,并触发前肢发育.
- FGF8诱导Fgf8基因表达在覆盖的外皮.
- FGF8促进外皮和底层中皮外生长和Sonic刺表达,启动和维持四肢芽的形成.
结论:
- FGF8是子四肢发育的关键内源诱导剂.
- FGF8在肢体芽形成的多个阶段起作用,从启动到持续生长.
- FGF8在肢体发育中的作用与胚胎脏分化机制相互联系.
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