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自我报告的女性卫生专业人员的乳房植入物和结缔组织疾病. 一个回顾性队列研究

C H Hennekens¹, I M Lee, N R Cook

¹Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA.

|February 28, 1996

概括

胸部植入器的女性显示,结合组织疾病的风险略有增加. 虽然排除了很大的风险,但自我报告的数据表明存在潜在的关联,尽管偏见是可能的解释.

科学领域:

医学研究医学研究
流行病学流行病学
整形外科整形外科整形外科

背景情况:

连接组织疾病 (CTD) 是一组影响连接组织的自身免疫性疾病.
人们担心乳房植入物和CTD之间可能存在关联.
之前的研究对这种关联产生了相互矛盾的结果.

研究的目的:

调查乳房植入物与患有连接组织疾病的风险之间的关联.
为了评估CTD的相对风险在女性和没有乳房植入物.

主要方法:

一项回顾性队列研究,涉及395,543名女性卫生专业人员.
1962年至1991年间通过邮寄问卷收集的数据.
考克斯的比例危险回归模型用于分析自我报告的CTD.

主要成果:

在乳腺植入体的女性中,观察到任何连接组织疾病的统计显著增加风险 (RR=1.24).
特定的CTD与其他连接组织疾病 (包括混合疾病) 一样显示出统计学意义.
类风湿性关节炎,肖格伦综合征和硬质皮肤病显示边缘显著性;系统性红斑狼没有.

结论:

这些发现表明,乳房植入体的女性中CTD风险略有增加,与以前的研究相符,排除了大危险.
样本的大小将偶然发现的可能性降到最低,但过度报告或选择性参与的偏见仍然是可能的.
这项和其他观察性研究对于排除乳房植入后CTD的重大风险至关重要.

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