食补充剂对血压的影响. 一个随机对照试验的元分析
H C Bucher1, R J Cook, G H Guyatt
1Department of Clinical Epidemiology and Biostatistics, McMaster University Medical Center, Hamilton, Ontario, Canada.
JAMA
|April 3, 1996
概括
补充可能会略微降低静缩血压,但不会降低腹缩血压. 需要进一步的研究来探索特定人群的潜在影响,特别是那些摄入不够的人群.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 临床试验 临床试验
背景情况:
- 高血压是全球主要的健康问题.
- 饮食因素,包括摄入量,正在研究它们在血压调节中的作用.
- 之前关于补充和血压的研究已经产生了混合的结果.
研究的目的:
- 系统地审查补充对血压的影响.
- 分析随机对照试验的数据,以确定对静缩和静缩血压的整体影响.
主要方法:
- 在MEDLINE和EMBASE数据库中进行了全面的文献搜索.
- 包括涉及补充与安慰剂的合格随机对照试验 (RCT).
- 来自33个RCT的数据,共计2412名患者,使用随机效应模型进行了分析.
主要成果:
- 综合分析表明,缩血压的统计显著降低为-1.27 mm Hg (P=.01).
- 腹筋血压没有显著降低 (-0.24 mm Hg;P=.49).
- 没有确定的调解者解释了血压降低观察到的差异.
结论:
- 补充可能会导致系统性血压的适度下降.
- 对透静血压的影响并不显著.
- 需要进行进一步的研究,以探索子群体的潜在益处,特别是那些摄入不够的人群.
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