肢体缺陷和胸取样:来自国际注册的结果,1992-1994年
1Klinik und Poliklinik fur Geburtshilfe, Universitatsspital Zurich, Zurich, Switzerland.
Lancet (London, England)
|February 24, 1996
概括
研究人员调查了在取胆样本 (CVS) 后对肢体缺陷的担忧. 对超过138,000例怀孕的分析显示,在CVS之后,四肢缺陷的风险增加或变化模式没有增加.
科学领域:
- 产前诊断 在产前诊断
- 甲状腺学 甲状腺学
- 生殖医学 生殖医学
背景情况:
- 报告显示,一些婴儿患有肢体缺陷,而这些婴儿接受了毛样本采集 (CVS),这引发了安全问题.
- 世界卫生组织 (WHO) 建立了一个国际注册表,以评估CVS后四肢缺陷的风险.
研究的目的:
- 在接受CVS的孕妇队列中评估四肢缺陷的真实风险.
- 为了确定CVS是否与肢体缺陷的发病率增加或变化的模式有关.
主要方法:
- 世界卫生组织从1992年5月到1994年5月对CVS后肢体缺陷进行国际登记.
- 分析了来自138,996例CVS怀孕的77例肢体缺陷病例,不包括综合征和遗传性疾病.
- 肢体缺陷的模式分析,包括横向和纵向缺陷.
主要成果:
- 肢体缺陷发生在77名婴儿/胎儿中,来自138,996例CVS怀孕.
- 上肢缺陷与下肢缺陷的分布以及横向与纵向缺陷的分布反映了背景人口研究.
- 在CVS的妊娠年龄和肢体缺陷的严重程度之间没有发现相关性.
结论:
- 该研究没有发现CVS后肢体缺陷风险增加的证据.
- 在CVS队列中,肢体缺陷的频率和模式与一般人群相似.
- 结果表明CVS与肢体缺陷风险增加无关.
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