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The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
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EGR-1诱导的内皮基因表达:血管损伤中的一个常见主题

L M Khachigian1, V Lindner, A J Williams

  • 1Vascular Research Division, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Science (New York, N.Y.)
|March 8, 1996
PubMed
概括

早期生长反应基因1 (Egr-1) 在动脉损伤后对升高调节血小板衍生生长因子B链 (PDGF-B) 和其他基因至关重要. 在受伤的内皮细胞中,EGR-1取代了Sp1,调解了这些强有力的介质的表达.

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