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在新生小鼠中诱导TH1和TH2免疫力

T Forsthuber1, H C Yip, P V Lehmann

  • 1Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-4943, USA.

Science (New York, N.Y.)
|March 22, 1996
PubMed
概括

新生儿"耐受性"协议不会诱导真正的免疫耐受性. 相反,它们会触发强烈的T辅助细胞2型 (TH2) 免疫反应,在新生儿中显示出免疫偏差.

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Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...