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TIMI框架数:评估冠状动脉流量的一种定量方法

C M Gibson¹, C P Cannon, W L Daley

¹Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

|March 1, 1996

概括

一种新的方法 - - 心肌梗塞纠正血栓溶解 (TIMI) 框架计数 (CTFC) - - 可以客观地测量冠状动脉血流. 这种可重复的CTFC方法提高了临床试验中TIMI流量等级的标准化.

科学领域:

心脏病学心脏病学
医疗成像医学成像
生理学生理学生理学

背景情况:

心肌梗塞中血栓溶解流量级 (TIMI) 是用于血管学试验的冠状动脉血液流量的主观,分类测量.
主观评估的局限性需要客观和定量方法来评估冠状动脉 perfusion.

研究的目的:

开发和验证冠状动脉血流的客观,连续变量指数.
建立一种可重复的方法来评估冠状动脉 perfusion 超出了定性 TIMI 流量等级的限制.

主要方法:

正确的心肌梗塞中血栓溶解 (TIMI) 框架计数 (CTFC) 方法是通过计算色素过渡到远端地标的 cineframes 来开发的.
评估了该方法的可重现性,并根据动脉长度的变化 (例如,左前下降动脉) 修正了数.
在正常的动脉,急性心肌梗塞 (MI) 冠状动脉中测量CTFC,在血栓溶解后,在非冠状动脉中测量CTFC.

主要成果:

通过CTFC方法证明了其可重复性.
血栓溶解后罪犯动脉中平均CTFC显著改善,从90分钟到18-36小时.
在CTFC改善和最小光径变化之间没有发现相关性.
早期的血栓溶解后CTFC在非罪祸首的动脉中比正常高 (流量较慢),但在1天后正常化.

结论:

纠正的TIMI数 (CTFC) 是冠状动脉流的简单,可重复,客观和定量指数.
CTFC允许TIMI流量等级的标准化,并促进血管学终点的试验间比较.
阻力血管功能障碍可能导致血栓溶解后的早期小时冠状动脉流量减少.

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