在小鼠胚胎中,TGFβ家族左派成员的左向右非对称表达
Nature
|May 9, 1996
概括
转化生长因子-β家族成员的基因lefty在小鼠胚胎中表达不对称,这表明它在建立左右 (L-R) 不对称性和器官定位方面的作用.
科学领域:
- 发展生物学 发展生物学
- 分子遗传学 分子遗传学
- 胚胎学 胚胎学
背景情况:
- 脊椎动物表现出横向不对称性,就像心脏的左侧位置一样,但潜在的分子机制仍然不清楚.
- 一种扩散性形态原被假设可以建立左-右 (L-R) 极性,但尚未确定任何特定的分子.
研究的目的:
- 确定控制脊椎动物左右 (L-R) 非对称性建立的分子机制.
- 调查左边基因在L-R决定中的潜在作用.
主要方法:
- 在胃化小鼠胚胎中分析左侧基因表达.
- 在表现出 situs inversus 的老鼠突变 (iv 和 inv) 中检查左撇子表达.
主要成果:
- 左侧基因,编码转化生长因子-β家族成员,表达在早期小鼠胚胎的左半部分.
- 这种不对称的左边表达是暂时的,并且在横向不对称的可见开始之前.
- 在有反向器官定位 (反向位置) 的突变小鼠中,左边表达模式也反向,表明左边是这些基因的下游.
结论:
- 左侧基因可能作为一种参与建立哺乳动物器官系统L-R不对称性的形态原体.
- 左边的不对称表达是导致器官横向性的布中的一个关键早期事件.
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