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在糖尿病小鼠中,丁受体的异常拼接

G H Lee1, R Proenca, J M Montez

  • 1Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA.

Nature
|February 15, 1996
PubMed
概括

小鼠糖尿病 (db) 基因的突变导致肥胖和糖尿病. 该db基因可能编码了瘦素受体,在db/db小鼠中缺陷的下丘脑结合变体,表明瘦素受体.

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RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...