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Examination of Thymic Positive and Negative Selection by Flow Cytometry
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Published on: October 8, 2012

T细胞与受体的亲和力和胸细胞的阳性选择

S M Alam1, P J Travers, J L Wung

  • 1Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

Nature
|June 13, 1996
PubMed
概括

对T细胞受体 (TCR) 与-MHC复合体的结合亲和力决定了胸细胞选择结果. 一个特定的亲和度窗口促进了积极的选择,而更高的亲和度触发了负面的选择,指导T细胞的发育.

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