通过LIM本体盒基因Lhx3对 pituitary 细胞系的规范
H Z Sheng1, A B Zhadanov, B Mosinger
1Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Science (New York, N.Y.)
|May 17, 1996
概括
在小鼠中,LIM homeobox 基因 Lhx3 对 pituitary 发育至关重要. 它的缺失阻止了拉特克囊的分化,影响了除皮质细胞以外的大多数垂体细胞系.
科学领域:
- 发育生物学 发展生物学
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 下垂体器官生成涉及从常见原始体中复杂的细胞分化.
- Lhx3 是一个LIM homeobox基因,对 pituitary 发育至关重要.
研究的目的:
- 研究Lhx3在垂体细胞系的分化和增殖中的作用.
- 了解下垂体细胞特征的发育途径.
主要方法:
- 在小鼠中向基因破坏,以创建Lhx3突变.
- 对同卵性Lhx3突变小鼠下垂体发育的分析.
主要成果:
- 对Lhx3突变同卵性小鼠表现出失败的拉特克囊生长和分化.
- 在突变小鼠中观察到前垂体和中间垂体叶的缺失.
- 大多数垂体细胞系的确定受影响,不包括皮质细胞系.
结论:
- Lhx3对于多个垂体细胞系的分化和增殖至关重要.
- 一个独特的Lhx3-独立的途径可能会支配皮质营养菌的初始规范.
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