关于心脏 natriuretic 产生的负载依赖和负载独立决定因素的证据
1University of Ottawa Heart Institute, Ottawa Civic Hospital, Ontario, Canada.
Circulation
|June 1, 1996
概括
高血压和心脏缩增加了性尿素 (NP) 产量. 拉米普利尔治疗有效地减少了这两种情况,较高的剂量使所有参数正常化,而较低的剂量则准高和原水平.
科学领域:
- 心血管生理学心血管生理学
- 药理学 药理学 是一个学科.
- 分子生物学分子生物学
背景情况:
- 高血压和心脏缩增加心脏 natriuretic (NP) 的生产.
- 在NP合成中,心脏负荷和高的不同作用尚不清楚.
- 这项研究研究了NP调节对大动脉带带和ACE抑制的反应.
研究的目的:
- 为了确定心脏负荷和高对尿素 (NP) 生产的贡献.
- 评估不同剂量的拉米普利尔对高血压,心脏缩和NP水平的影响.
- 评估拉米普利尔对心室重塑标记物的影响,如原和肌肉素重链 (MHC) 异型.
主要方法:
- 在老鼠中,进行了上大动脉带带,以诱导高血压和高.
- 大鼠接受高剂量 (1毫克/千克) 或低剂量 (10微克/千克) 拉米普利尔治疗.
- 测量包括血压,心脏缩标志物,血和心室NP水平,NP mRNA,原III mRNA和β-MHC mRNA.
主要成果:
- 大动脉带纹增加了血压,心脏重量,NP水平,以及原III和β-MHC mRNA.
- 高剂量的拉米普利尔使所有测量参数正常化.
- 低剂量的拉米普里尔使心脏体重和原III mRNA正常化,但不使血压或β-MHC mRNA正常化.
结论:
- 氨酸的产生是独立由血压和高调节的.
- 心脏负荷是左心室NP生产的更重要的驱动因素,而不是单独的过度缩小.
- 低剂量的拉米普利尔有效地逆转了缩和原沉积,但没有β-MHC异型变化,表明独立调节.
- 耳前NP的产生仍然不受大动脉带或ACE抑制的影响.
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