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人类动脉样硬化中E-selectin,细胞间粘附分子-1和血管细胞粘附分子-1的新血管表达及其与内脏白细胞含量的关系
K D O'Brien1, T O McDonald, A Chait
1Department of Medicine, University of Washington, Seattle 98195-6422. cardiac@u.washington.edu
Circulation
|February 15, 1996
概括
像VCAM-1和ICAM-1这样的白细胞粘附分子在动脉样硬化中的亲密新血管上更为普遍. 它们的存在与白细胞积累的增加有关,这表明它们在疾病发病过程中发挥了作用.
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 白血球的招募是动脉样硬化的早期事件.
- 白细胞粘附分子 (E-selectin,ICAM-1,VCAM-1) 在人类动脉样硬化中被发现.
- 以前的研究没有详细说明这些分子在动脉内心的分布或它们与斑块白细胞含量的关系.
研究的目的:
- 评估E-selectin,ICAM-1和VCAM-1在动脉内心不同部位的分布.
- 为了确定这些粘附分子与斑块白细胞含量之间的关系.
主要方法:
- 99个冠状动脉段的免疫组织化学 (34个对照组,65个动脉样硬化).
- 检测E-选择素,ICAM-1,VCAM-1,巨细胞,光滑肌细胞和T淋巴细胞.
- 对内巨细胞和T淋巴细胞密度的评分 (0-3级).
主要成果:
- 粘附分子的患病率在斑块新血管学上是光线内皮的两倍.
- 发光内皮上的E-选择蛋白表达在斑块中高于对照组.
- 新血管和非内皮细胞上的VCAM-1和ICAM-1表达与密切的巨细胞和T淋巴细胞密度的增加相关.
结论:
- 白细胞粘附分子表达在内密新血管上高于动脉样硬化斑块中的光线内皮.
- 新血管和非内皮细胞上VCAM-1和ICAM-1的存在与白细胞积累密切相关.
- 在动脉样硬化的发病过程中,内极性新血管可能对白细胞的招募和激活至关重要.
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