草的光激活导电性由两个通道TRP和TRPL组成
B A Niemeyer1, E Suzuki, K Scott
1Howard Hughes Medical Institute, Department of Biology, Department of Neurosciences, University of California at San Diego, La Jolla, California 92093-0649, USA.
Cell
|May 31, 1996
概括
这项研究表明,短暂受体潜能 (TRP) 和短暂受体潜能类 (TRPL) 离子通道都形成了Drosophila的光激活导电,在光传导中部分重叠功能.
科学领域:
- 分子生物学分子生物学
- 神经科学是一个神经科学.
- 离子通道生理学 离子通道生理学
背景情况:
- 多虫光传导是G蛋白结合,调节的脂酶C (PLC) 信号传导的模型.
- 暂时受体潜力 (TRP) 离子通道是光激活导电量的一部分,但其他通道也参与其中.
研究的目的:
- 为了研究过渡受体潜力样 (TRPL) 基因及其蛋白质产物的Drosophila光传导中的功能.
- 为了确定离子通道在光激活导电中的组成和作用.
主要方法:
- 分离和生理/遗传特征在Drosophila.trpl突变的突变.
- 在光传导器官内对TRP和TRPL蛋白的定位研究.
- 在野生类型和突变中对光激活导电的电生理学分析.
主要成果:
- TRP和TRPL蛋白与罗多普辛和PLC局部化到膜上.
- 光激活电导率由TRP和TRPL离子通道组成.
- 每种通道类型 (TRP和TRPL) 都可以独立激活,并且它们具有部分重叠的功能.
结论:
- TRPL是Drosophila光激活离子通道复合物的功能组成部分.
- TRP和TRPL通道有助于光传导,其重叠的作用突出显示了它们在视觉信号传输中的重要性.
相关概念视频
01:11Channel Rhodopsins
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
01:21G-Protein Gated Ion Channels
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Sensory organs,...