长期功能不良但可行的心肌中葡萄糖的吸收
M Mäki1, M Luotolahti, P Nuutila
1Department of Clinical Physiology, University of Turku, Finland.
Circulation
|May 1, 1996
概括
胰岛素显著增加了人类慢性功能障碍但活力的心脏肌肉中的葡萄糖吸收. 这一发现支持对心脏病的代谢干预,以保持胰岛素敏感性.
科学领域:
- 心脏病学 心脏病学
- 核医学是一种核医学.
- 代谢研究研究 代谢研究
背景情况:
- 人类研究缺乏对功能障碍但可行的心肌中葡萄糖吸收调节的研究.
- 慢性心肌功能障碍可能是冠状动脉堵塞的结果.
研究的目的:
- 为了研究慢性功能障碍但可行的人类心肌中葡萄糖摄取调节.
- 为了确定胰岛素在这些特定条件下对心肌葡萄糖吸收的影响.
主要方法:
- 使用2--2-脱氧-D-葡萄糖 (FDG) 的正子发射断层扫描 (PET) 用于测量葡萄糖吸收.
- 超胰岛素高血糖结评估了胰岛素对葡萄糖吸收的影响.
- 用氧气-15标记的水 (H2O) 来测量心肌血流量.
主要成果:
- 功能失调的心肌显示血液流量略有减少,但在禁食状态下葡萄糖吸收增加.
- 胰岛素紧诱导了异常和正常心肌区域的葡萄糖吸收显著增加.
- 患者的再血管化证实了组织活力和随后的墙壁运动恢复.
结论:
- 胰岛素介导的葡萄糖吸收在慢性功能障碍但活力的心肌中保持.
- 这些发现为在患有这种心肌疾病的患者中使用代谢干预提供了基础.
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