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间歇性关节障碍患者的卡尼丁相关变化:针对焦点卡尼丁治疗的指示
G Brevetti1, F di Lisa, S Perna
1Department of Medicine, University Federico II, Naples, Italy.
Circulation
|May 1, 1996
概括
补充L-卡尼丁可以改善周围动脉疾病患者的行走性能. 测量血乙卡尼丁水平可以识别那些将受益于这种治疗的患者.
科学领域:
- 生物化学 生物化学
- 心血管医学 心血管医学
- 营养科学 营养科学
背景情况:
- 周围动脉疾病 (PAD) 与改变的卡尼丁代谢有关.
- 补充L-carnitine是PAD的潜在治疗策略.
研究的目的:
- 为了研究L-卡尼丁对卡尼丁代谢和间歇性巴患者的步行表现的影响.
- 为了确定PAD中L-卡尼丁反应的潜在生物标志物.
主要方法:
- 血卡尼丁和水平在休息状态和运动后测量在22名静音患者和8名对照组中.
- 患者接受了安慰剂或L-卡尼丁 (500毫克静脉注射),并重复了该方案.
- 根据休息和运动时的乙甲尼丁水平,患者被分为两组.
主要成果:
- 两组患者出现了:一个患者对炼的反应正常 (IC1),另一个患者的休息水平升高,炼反应降低 (IC2).
- 组IC2患者的行走能力低于组IC1.
- 在大多数IC2患者中,L-卡尼丁的使用改善了行走能力,并使乙卡尼丁对运动的反应正常化,但在IC1患者中并非如此.
结论:
- 休息和运动后的血乙卡尼丁水平可以识别间歇性闭塞患者,这些患者可能会对L-卡尼丁治疗做出反应.
- 这种评估可以指导选择在PAD治疗L-carnitine的目标人群.
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