慢性酸盐中毒和严重的疟疾
M English1, V Marsh, E Amukoye
1Clinical Research Centre, Kenya Medical Research Institue, Kilifi Unit, Kilifi, Kenya.
Lancet (London, England)
|June 22, 1996
概括
酸盐中毒是非洲儿童的一个重大问题,经常模仿严重的疟疾症状. 许多用非处方药治疗发烧的儿童的酸盐水平很高,导致严重的并发症.
科学领域:
- 儿科 儿科 儿科
- 毒理学 毒理学 毒理学
- 传染性疾病 传染性疾病
背景情况:
- 酸盐在发展中国家被广泛用作非处方药 (OTC) 抗发烧药.
- 由于安全问题,发达国家对儿童的酸盐使用受到限制.
- 酸盐中毒症状与非洲儿童的严重疟疾重叠.
研究的目的:
- 调查肯尼亚严重疟疾儿童酸盐中毒的发生率和影响.
- 评估社区对发烧儿童使用含有酸盐的OTC药物的使用情况.
主要方法:
- 一项研究对儿童 (6个月至10岁) 进行了研究,这些儿童被确诊患有Plasmodium falciparum疟疾和严重症状.
- 在血液样本中测量了酸盐度.
- 通过对家庭进行调查和对母亲进行关于OTC药物使用的采访,评估了社区的发烧管理.
主要成果:
- 在143名患有严重疟疾的儿童中,有129名 (90%) 患有可检测的酸盐水平.
- 六名儿童的盐酸盐酸度高 (≥20毫克/分升),表现为神经功能障碍,代谢酸和低血糖症.
- 非处方药是常见的第一线治疗发烧的药物,94%的母亲购买含酸盐的药物,21%的母亲超过了推剂量.
结论:
- 酸盐中毒可能导致或引起严重疟疾儿童的代谢酸和低血糖症.
- 这些症状的重叠可能会使诊断和管理变得复杂,可能会增加死亡率.
- 在疟疾流行地区,明智使用和对OTC抗热药的家长教育至关重要.
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