一种编码人类乳头瘤病毒类型16和18型,E6和E7蛋白质的重组疫苗病毒,用于宫癌的免疫治疗
L K Borysiewicz1, A Fiander, M Nimako
1Department of Medicine, University of Wales College of Medicine, Cardiff, UK.
Lancet (London, England)
|June 1, 1996
概括
使用复合疫苗病毒的新型疫苗 (TA-HPV) 在宫癌患者的I/II期试验中显示出有前途的安全性和免疫性. 对于其在免疫疗法中的使用,需要进一步的研究.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 人类乳头瘤病毒 (HPV) 类型16和18与子宫癌有关.
- HPV 型蛋白 E6 和 E7 在瘤发育中至关重要.
- TA-HPV是一种活生生的重组疫苗病毒,表达HPV 16/18 E6和E7蛋白质.
研究的目的:
- 评估TA-HPV的临床和环境安全性.
- 为了评估TA-HPV的免疫性,首次在人体上进行试验.
- 探索TA-HPV作为宫癌的潜在免疫疗法.
主要方法:
- 一个开放的I/II期临床试验.
- 八名晚期宫癌患者接受了一次TA-HPV剂量.
- 监测包括副作用,环境传播和免疫反应.
主要成果:
- TA-HPV证明了良好的临床安全性,没有显著的副作用.
- 没有发现活体TA-HPV对环境的污染.
- 三名患者产生了HPV特异性抗体;一名患者出现了HPV特异性细胞毒性T淋巴细胞.
结论:
- 在宫癌患者中,TA-HPV是安全和免疫的.
- 这种疫苗会引起HPV特异性的免疫反应.
- 建议进一步研究TA-HPV用于宫癌免疫疗法.
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