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Updated: Aug 11, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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在Stat4缺乏的小鼠中,IL-12反应受损和Th2细胞的增强发育

M H Kaplan1, Y L Sun, T Hoey

  • 1Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Nature
|July 11, 1996
PubMed
概括

信号转换器和转录4激活器 (STAT4) 对于介质蛋白-12 (IL-12) 反应至关重要. STAT4 缺陷取消了IL-12 诱导的干扰素玛生成,并损害了T辅助细胞的分化.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...