55岁及以下的男性血脂蛋白升高和冠状动脉心脏病. 一个前性研究研究
A G Bostom1, L A Cupples, J L Jenner
1Framingham Study, Epidemiology and Biometry Program, Framingham, Mass., USA.
JAMA
|August 21, 1996
概括
升高的脂蛋白 (Lp) 是男性早发冠心病 (CHD) 的重要独立风险因素. 这一发现与高胆固醇或低高胆固醇水平相提并论,强调Lp (a) 作为心血管风险关键指标.
科学领域:
- 心血管医学 心血管医学
- 脂质学 脂质学是指脂质学.
- 预防性心脏病学 预防性心脏病学
背景情况:
- 脂蛋白 (Lp) 是一种与心血管风险相关的脂蛋白颗粒.
- 以前的研究表明,升高的Lp(a) 水平与冠状动脉心脏病 (CHD) 之间存在潜在联系.
- 了解Lp (a) 所带来的独立风险对于完善心血管风险评估策略至关重要.
研究的目的:
- 要确定是否升高的脂蛋白 (Lp) 是男性早发冠心病 (CHD) 的独立风险因素.
- 为了将与升高的Lp (a) 相关的风险与其他已确定的心血管疾病风险因素进行比较.
主要方法:
- 使用弗雷明汉姆后代队列进行了一项前性研究.
- 2191名20-54岁的男性,在基线 (1971-1975) 时没有心血管疾病,被跟踪.
- 发生性心血管疾病事件被追踪到55岁,用于风险估计的比例危险模型.
主要成果:
- 平均随访时间为15.4年后,发生了129起心血管疾病事件.
- 升高的Lp (a) 显示出早期慢性心血管疾病的相对风险 (RR) 为1.9 (95% CI,1.2-2.9).
- 升高Lp (a) 的RR与高总胆固醇 (RR 1.8) 和低HDL (RR 1.8) 相当.
结论:
- 血Lp (a) 的升高被证实是男性早期心脏病的独立危险因素.
- 升高Lp (a) 的风险的大小和患病率与高总胆固醇或低HDL水平相当.
- 在评估个人患早发性心血管疾病的风险时,应将Lp (a) 作为一个重要因素.
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