人类对内毒素的局部静脉反应
K Bhagat1, J Collier, P Vallance
1Centre for Clinical Pharmacology, University College London Medical School, UK.
Circulation
|August 1, 1996
概括
静脉内内毒素的灌注会导致对诺拉上腺素的暂时低反应,由皮消除. 重复暴露于内毒素会导致血管耐受性,影响毒性休克研究中的血管收缩反应.
科学领域:
- 血管生物学 血管生物学
- 药理学 药理学是指药理学的学科.
- 败血性休克研究研究.
背景情况:
- 败血性休克涉及血管扩张和降低血管缩器反应能力.
- 开发了一种新方法来研究内毒素对血管的 in vivo 影响.
研究的目的:
- 为了研究内毒素对血管收缩剂的血管反应的影响.
- 阐明底层的机制内毒素诱导的血管低反应.
主要方法:
- 内毒素被灌注到手背静脉中,随后进行了诺尔阿皮内林剂量反应曲线.
- 在暴露于内毒素之前和之后的不同时间点评估了血管反应.
- 使用特定抑制剂和皮质,探索了循环氧化酶,氧化合成酶和葡萄糖皮质激素的参与.
主要成果:
- 内毒素诱导了北上腺素剂量反应曲线的显著向右转移,表明了低反应性.
- 在受内毒素治疗的静脉中,交感介导和药物诱导的静脉缩反应被废除.
- 重复给予内毒素导致了血管耐受性的发展.
结论:
- 内毒素会导致葡萄糖皮质类药物抑制的对诺尔上腺素的低反应,并消除静脉收缩.
- 对内毒素的急性反应并非由氧化或前列腺介导.
- 对内毒素的直接血管耐受性会随着重复的使用而发展.
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