非A非B型肝炎与慢性肝病相关,在血液透析单位进行
Lancet (London, England)
|May 5, 1979
概括
甲型肝炎病毒没有参与1968-70年富勒姆医院非A非B型肝炎的爆发. 这项研究排除了甲型肝炎病毒作为脏病患者急性或慢性肝炎的原因.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 在1968年至1970年期间,在病房发生了一次肝炎爆发.
- 肝炎是HBsAg阴性 (乙型肝炎表面抗原阴性).
- 一些患者随后患上慢性肝病.
研究的目的:
- 为了确定HBsAg阴性肝炎爆发的病因.
- 调查甲型肝炎病毒 (HAV) 在疫情爆发中的潜在作用.
- 评估HAV在随后的慢性肝病中的作用.
主要方法:
- 在存储的血清样本上进行抗HAV (甲型肝炎病毒抗体) 的回顾性血清检测.
- 从29名感染患者中,分析了24名感染患者的配对血清样本.
- 随着时间的推移,对抗HAV标位的变化进行了监测.
主要成果:
- 在大多数患者中,没有发现抗HAV标位的显著增加.
- 一名患者的抗HAV标位略有增加,两名患者的抗HAV标位略有下降.
- 这些发现并不支持甲型肝炎病毒参与疫情.
结论:
- 甲型肝炎病毒不太可能导致这种急性肝炎的爆发.
- 排除了甲型肝炎病毒作为病发后观察到的慢性肝病的原因.
- 疫情可能是非A非B型肝炎,此前在英国血液透析单位没有报告,并与持续的肝功能障碍有关.
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