控制怀孕生理性缩的控制机制
S M Mone1, S P Sanders, S D Colan
1Department of Cardiology, Children's Hospital, Boston, MA 02115, USA.
Circulation
|August 15, 1996
概括
怀孕导致心脏收缩率暂时下降,由血压和体积的变化来控制. 心脏适应其尺寸,以保持在怀孕期间和怀孕后的功能.
科学领域:
- 心血管生理学心血管生理学
- 生殖医学 生殖医学
- 进行心脏重塑.
背景情况:
- 怀孕是由于血液动力学变化而导致的生理性缩和缩的模型.
- 研究了怀孕对心室力学的影响.
研究的目的:
- 测试怀孕期间心脏适应作为服务机制的假设.
- 识别墙壁应力作为这个过程中的关键反变量.
主要方法:
- 在正常怀孕期间和之后,对33名妇女进行了连续研究.
- 使用的负载独立的收缩率指数.
- 监测心室尺寸,壁厚度和左心室质量.
主要成果:
- 在怀孕期间,分数缩短和缩短速度下降.
- 心脏指数增加,峰值壁应力提升早期,然后由于补偿性缩正常化.
- 左心室质量变化与峰值壁应力相关.
结论:
- 正常的怀孕涉及到心脏收缩率的可逆性下降.
- 缩功能通过减少后负载而维持,但近期下降.
- 左心室缩/缩小与血液动力负荷有关,这表明有服务机制.
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