循环长度依赖于心肌上加重负荷对心肌的电生理效应
S M Horner1, D J Dick, C F Murphy
1British Heart Foundation Cardiac Arrhythmia Research Group, Department of Physiology, Charing Cross and Westminster Medical School, London, UK.
Circulation
|September 1, 1996
概括
在变化的负载下,机电反会改变心脏的电生理学. 动力潜力持续时间和电还原性质的这些变化可能会促进心律失常.
科学领域:
- 心血管生理学心血管生理学
- 心脏电生理学 心脏电生理学
背景情况:
- 机电反将机械活动与心肌电生理学联系起来.
- 这一过程与心律不整的发展有关.
研究的目的:
- 通过检查动力电位持续时间和电还原的变化来研究心律失常机制.
- 评估暂时负载变化对这些电生理学参数的影响.
主要方法:
- 在麻醉后的猪身上进行了实验,这些猪有过渡性大动脉闭塞,以改变心脏负荷.
- 测量包括心室压力,单相动力潜力和细分运动.
- 在正常和变化的负载条件下生成了电力还原曲线.
主要成果:
- 行动潜力的持续时间缩短在封闭期间减少与更短的节拍间隔节拍.
- 增加负载减少了平原行动潜力的持续时间,但增加了早期行动潜力的持续时间.
- 增加的负载使最大斜率变得更,并延长了电力归还曲线的超正常周期.
结论:
- 机电反会诱导取决于速率的电生理变化.
- 电生理学中的这些变化可能会为心律失常产生有利条件.
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