持续活动的动力学:解释引起的皮质反应的巨大变异性
A Arieli1, A Sterkin, A Grinvald
1Department of Neurobiology, Weizmann Institute of Science, Post Office Box 26, Rehovot 76100, Israel.
Science (New York, N.Y.)
|September 27, 1996
概括
大脑对刺激反应的变化是由持续的神经活动引起的. 这种持续的活动,反映了大脑的活动.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 哺乳动物的皮质活动和行为反应对相同的刺激有显著的变化.
- 了解这种神经变化的来源对于破译大脑功能至关重要.
研究的目的:
- 调查是否正在进行的神经活动是哺乳动物皮质响应变异的主要原因.
- 确定正在进行和唤起的神经活动模式之间的关系.
主要方法:
- 实时光学成像用于测量猫视觉皮层中的时空活动模式.
- 电生理学技术同时记录了局部场势和单个神经元放电.
主要成果:
- 发现唤起的活动是决定性的.
- 响应的变化直接归因于正在进行的神经活动的动态状态.
- 通过将确定性唤起的反应与之前的持续活动相结合,可以预测单个试验的反应.
结论:
- 持续的神经活动显著影响并解释了引起皮质反应的变化.
- 皮质网络的瞬间状态,反映在正在进行的活动中,对于处理至关重要.
- 持续的活动在皮质功能和认知过程中起着至关重要的作用,不应被忽视.
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