短期的triiodothyronine在预防暂时的甲状腺功能低下症后亚总的甲状腺切除术的坟墓病
Lancet (London, England)
|July 14, 1979
概括
短期的三甲状腺素 (T3) 替代疗法有效地预防了在Graves病手术后的临时甲状腺功能低下症. 这种甲状腺激素治疗不会延迟,而是预防这种情况,而不会增加永久性甲状腺功能低下的风险.
科学领域:
- 内分泌学 在内分泌学.
- 外科手术患者管理
背景情况:
- 格雷夫斯病是一种自身免疫性疾病,导致甲状腺功能增强症.
- 副总体甲状腺切除术是对格雷夫斯病的常见手术治疗方法.
- 手术后的甲状腺功能低下症是需要治疗的常见并发症.
研究的目的:
- 调查短期甲状腺激素替代是否可以预防或延迟Graves病后的临时性甲状腺功能低下.
- 评估三氨酸 (T3) 替代剂对术后甲状腺功能的影响.
主要方法:
- 研究了两个由18名患者组成的小组,这些患者接受了Graves病的甲状腺切除术.
- 第一组接受了T3 (20毫克克,每天4次) 在手术后12个月.
- 第二组没有接受甲状腺激素治疗;血清T3,TSH和T4水平被监测了18个月.
主要成果:
- 在II组 (不接受治疗) 的18名患者中,有10名患者出现了暂时的甲状腺功能低下.
- 在I组 (T3治疗) 中没有出现过时的甲状腺功能低下症.
- I组的T4水平在T3退出后的2个月内正常化,类似于II组.
结论:
- 短期的T3替代疗法可以在Graves病手术后预防暂时的甲状腺功能低下.
- 预防不是延迟,因为甲状腺激素水平在治疗后恢复正常.
- 这种策略不会增加永久性甲状腺功能低下的发病率.
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