对男性吸烟和与年龄相关的黄斑变性风险的前性研究
W G Christen1, R J Glynn, J E Manson
1Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass, USA.
JAMA
|October 9, 1996
概括
吸烟显著增加了男性与年龄相关的黄斑变性 (AMD) 的风险. 与非吸烟者相比,目前重度吸烟者患AMD的风险是非吸烟者的2.46倍.
科学领域:
- 眼科医生 眼科 眼科
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 与年龄相关的黄斑变性 (AMD) 是老年人视力丧失的主要原因.
- 生活方式因素 (如吸烟) 在AMD发展中的作用需要进一步调查.
研究的目的:
- 调查吸烟与与年龄相关的黄斑变性病 (AMD) 在美国男性医生的大量队列中的发生率之间的关联.
主要方法:
- 一项前性队列研究,涉及来自医生健康研究的21157名美国男性医生.
- 对参与者进行了平均12.2年的随访,以确定AMD的发病率,定义为由医疗记录确认的自我报告,并导致视力丧失至20/30或更差.
- 基线吸烟状态被分为当前,过去和从未吸烟者.
主要成果:
- 总共有268例发生的AMD病例与视力损失得到证实.
- 与从未吸烟者相比,目前每天吸烟20支或更多支烟的人患AMD的风险显著增加 (RR,2.46;95% CI,1.60-3.79).
- 过去的吸烟者在AMD风险中显示出适度而非显著的增加 (RR,1.30;95% CI,0.99-1.70).
结论:
- 未来的数据支持这样一个假设,即吸烟是患上与年龄相关的黄斑变性发病的危险因素.
- 沉重吸烟 (每天≥20支烟) 与男性的AMD风险显著增加有关.
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