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在最近出现的胰岛素依赖糖尿病中,细胞介导的对β素的免疫反应:对疾病发病的影响
M G Cavallo1, D Fava, L Monetini
1Cattedra di Endocrinologia (I), Policlinico Umberto I, University of Rome, La Sapienza.
Lancet (London, England)
|October 5, 1996
概括
早期牛奶消费可能会引发与胰岛素依赖糖尿病 (IDDM) 相关的免疫反应. 研究人员在IDDM患者中发现了T淋巴细胞对β-素的特定反应,这表明与胰腺β细胞的交叉反应.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 糖尿病研究 糖尿病研究
背景情况:
- 牛奶假说表明,早期摄入牛奶可能会引发导致胰岛素依赖糖尿病 (IDDM) 的自身免疫反应.
- 这个假设是基于牛奶蛋白和胰腺β细胞抗原之间的潜在免疫交叉反应.
研究的目的:
- 调查牛奶蛋白暴露与近期IDDM患者免疫反应之间的关联.
- 为了确定对牛奶蛋白的免疫反应是否与IDDM特异.
主要方法:
- 在47名IDDM患者,36名健康对照患者和10名自身免疫性甲状腺疾病患者中测量了对β-casein的外周淋巴细胞反应.
- 测试对其他抗原的反应,包括牛血清白蛋白,纯化蛋白衍生物,人血清白蛋白和特定性的植物凝素.
主要成果:
- 与健康人 (p < 0.00001) 和甲状腺疾病患者 (p < 0.002) 相比,在IDDM患者中观察到显著更高的T淋巴细胞增殖比β-素.
- 51.1%的IDDM患者对β-素有积极反应,相比之下,2.7%的健康人群和0%的甲状腺疾病患者 (p < 0.00001).
- 对于其他测试的抗原,两组之间没有发现淋巴细胞反应的显著差异.
结论:
- 这些发现支持牛奶假说,通过证明IDDM患者对β-素的特异性免疫反应.
- 这种细胞和幽默抗β-素免疫反应可能与胰腺β细胞抗原发生交叉反应,可能导致IDDM的发展.
- 观察到β-素和β细胞分子之间的序列同质性要求进一步研究交叉反应的机制.
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