用前列腺特异性抗原进行前列腺癌的纵向查
D S Smith1, W J Catalona, J D Herschman
1Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
JAMA
|October 23, 1996
概括
连续前列腺特异性抗原 (PSA) 查显示,四年来异常结果和癌症检测率下降. 这种方法将检测转移到老年男性早期的前列腺癌,低度前列腺癌.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 使用前列腺特异抗原 (PSA) 进行前列腺癌查是广泛讨论的主题.
- 了解合规性趋势,检测率和癌症特征对于评估查计划至关重要.
研究的目的:
- 分析基于PSA的连续查的最初四年趋势.
- 为了评估合规性,异常测试结果的流行率,癌症检测率,以及检测到的癌症的阶段/等级.
主要方法:
- 一项基于社区的研究,涉及用于前列腺癌查的连续PSA测量.
- 10248名50岁以上的男性志愿者每六个月进行一次查,至少持续48个月.
主要成果:
- 查合规度仍然很高,79%的人在48个月后回归.
- 观察到PSA水平升高 (4.0 ng/mL),癌症检测率和临床晚期癌症的降低.
- 在手术治疗的男性中,高度和病理发达癌症的减少被注意到.
结论:
- 连续PSA查导致异常结果较少,癌症检测率接近人口发病率.
- 查有助于在较早的临床阶段和较低等级检测癌症.
- 需要进一步进行成本效益分析,以确定这些检测转变的经济影响.
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