对复合血小板因子4与原胺进行随机试验,以逆转人类氨酸抗凝作用
G J Dehmer1, R A Lange, D A Tate
1Cardiac Catheterization Laboratories, University of North Carolina Hospitals, Chapel Hill 27514, USA.
Circulation
|November 1, 1996
概括
再组合血小板因子4 (rPF4) 有效地逆转了肝素抗凝作用,没有显著的副作用,显示出作为心脏手术中蛋白质胺更安全的替代品的前景.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 质氨酸用于逆转肝素抗凝作用,但具有不良影响的风险.
- 再组合血小板因子4 (rPF4) 正在作为一种潜在的替代蛋白质胺的替代品进行研究.
研究的目的:
- 为了比较静脉注射rPF4与protamine在逆转肝素抗凝的安全性和有效性.
主要方法:
- 一个随机盲目的试验,涉及81名接受心脏导管治疗的患者.
- 患者在肝素给药后接受了蛋白质胺或RPF4.
- 血动力学和凝血功能 (ACT,aPTT) 在给药后被连续监测.
主要成果:
- 在rPF4和原胺组之间,激活凝血时间 (ACT) 或激活部分血栓形成时间 (aPTT) 没有显著差异.
- 在rPF4组在以后的时间点观察到ACT和aPTT的轻微,临床上无意义的增加.
- 两组之间没有血液动力学变量或严重不良事件的临床意义上的差异.
结论:
- 静脉输入的rPF4耐受性良好,并且在研究剂量时有效地逆转了肝素的抗凝剂作用.
- 在心脏外科手术中,rPF4显示出作为前胺安全替代品的潜力,用于肝素逆转.
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