影响体外受精治疗结果的因素
A Templeton1, J K Morris, W Parslow
1Human Fertilisation and Embryology Authority, London, UK.
Lancet (London, England)
|November 23, 1996
概括
在体外受精 (IVF) 的成功率受到患者年龄,不孕症持续时间和先前怀孕史的影响. 这些因素,以及临床成功率,有助于预测个人体外受精结果.
科学领域:
- 生殖医学 生殖医学
- 临床流行病学临床流行病学
背景情况:
- 试管婴儿受精 (IVF) 治疗的有效性受到临床成功率和患者特定因素的影响.
- 自1991年以来,人类受精和胚胎管理局 (HFEA) 收集了英国IVF数据,以分析治疗结果.
- 本研究确定了影响试管婴儿治疗成功的关键因素.
研究的目的:
- 确定和量化影响体外受精 (IVF) 治疗结果的重要因素.
- 建立个体试管婴儿成功率的预测模型,考虑患者特征和临床绩效.
主要方法:
- 分析了1991年8月至1994年4月期间登记的36961次试管婴儿周期,不包括捐赠,冷胚胎移植和微操作周期.
- 使用后勤回归模型来评估患者因素 (年龄,不孕持续时间,先前怀孕) 与每个周期活产率之间的关系.
- 使用分数多项式分析了年龄,同时分析了其他因素,包括年龄在模型中.
主要成果:
- 总体的活产率为13.9%. 在25-30岁的女性中,成功率达到顶峰,在老年人群中急剧下降.
- 捐赠卵子改善了30岁以上妇女的活产率. 活产率随着不孕持续时间 (1-12年) 的增加而显著下降.
- 以前的怀孕和活产增加了成功率,而随后的每一个试管婴儿周期都降低了成功的可能性. 医疗指示没有显著影响结果.
结论:
- 后勤回归成功地确定了影响试管婴儿结果及其程度的重要因素.
- 这些确定的因素对于准确评估和预测试管婴儿治疗结果至关重要.
- 纳入这些因素可以更精确地预测个体体外受精结果,超出一般诊所的成功率.
相关概念视频
Spermatogenesis
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...


