维护了对酸甘的血管扩张反应在沙芬静脉旁路移植中
H Berglund1, H Luo, T Nishioka
1Department of Cardiology, Huddinge (Sweden) Hospital (Karolinska Institute).
Circulation
|December 1, 1996
概括
酸甘油有效地扩大动脉样硬化冠状动脉和软静脉绕道移植,即使在没有明显病变的部分. 这表明这些血管的血管扩张能力得到保护.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 血管生物学 血管生物学
背景情况:
- 关于酸甘对动脉样硬化冠状动脉段的影响存在不确定性.
- 有限的数据可用于saphenous静脉旁路移植的血管活性.
- 血管内超声波 (IVUS) 可以检测动脉样硬化在血管图形上正常的段落,并测量光线区域的变化.
研究的目的:
- 为了评估静脉内酸甘油对动脉样硬化原生冠状动脉和沙静脉绕道移植的作用.
- 使用IVUS在没有血管学上明显的病变的段落中评估血管活性.
主要方法:
- IVUS用于评估冠状动脉样硬化患者的血管形态和面积.
- 尼甘油 (100-200微克) 被静脉注射,每10秒间隔60秒进行测量.
- 沙芬静脉旁路移植 (n=11) 与本土冠状动脉 (n=16) 相比较.
主要成果:
- 在尼特洛甘油后,在本土动脉和旁路移植中观察到显著的光线面积增加.
- 最大膜面积扩张是可比的:19.6%在移植器 vs 19.7%在本土动脉.
- 与本土动脉 (44.7s;P=.003) 相比,软静脉移植显示出较早的峰值血管扩张反应 (34.5s).
结论:
- 血管内超声波检查显示了血管学上正常的冠状动脉段的显著动脉样硬化.
- 原生冠状动脉和沙芬静脉旁路移植都表现出随着静脉内酸甘的迅速血管扩张.
- 尼糖的血管扩张能力似乎保留在无静脉移植中,尽管转移,化和脱细胞化.
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