内生细胞播种. 内生细胞播种. 支架后剩余的内皮增强了血管修复
C Rogers1, S Parikh, P Seifert
1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA. cdrogers@bics.bwh.harvard.edu
Circulation
|December 1, 1996
概括
内血管支架比气球血管造形术更少造成内皮损伤,从而减少了neointimal加厚和改善了血管修复. 这表明,在支架后部分内皮质保留可以调节愈合.
科学领域:
- 血管生物学 血管生物学
- 生物医学工程 生物医学工程
- 干预性心脏病学 干预性心脏病学
背景情况:
- 内皮完整性对于血管稳定至关重要;脱皮导致新极致的加厚.
- 气球可扩展的内血管支架提供脚手架,内皮接触最小.
- 研究了由支架造成的内皮损伤的程度及其对增殖的影响.
研究的目的:
- 为了确定内血管支架与气球血管塑造相比,是否会导致较少的内皮切除.
- 评估内皮损伤程度是否会影响后续的增殖反应.
- 评估部分内皮质保留的潜力,以调节支架后的血管修复.
主要方法:
- 不钢支架在正常或剥离的子下动脉中被扩展.
- 静脉在造后的不同时间点 (15分钟至14天) 收获.
- 面部染色评估了内皮细胞的损失和再生;亲密的加厚和巨细胞的积累被量化.
主要成果:
- 内皮细胞损失发生在支架扩张后立即,局部在支架之间.
- 在3天内观察到完全的内皮再生,在支架的部分.
- 非气球化,带有支架的动脉显示,单细胞粘附和内脏巨细胞减少了80%以上,与气球化动脉相比,内脏加厚减少了两倍.
结论:
- 内皮损伤程度是支架诱导的新发性增生和血管修复的关键因素.
- 支架和气球的设计/使用应考虑内皮损伤.
- 主要支架可能允许部分内皮保留,调节修复,并可能减少需要药理疗法的需要.
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