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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
出生体重,中年人体质量指数,以及发生的冠心病
S Frankel1, P Elwood, P Sweetnam
1Department of Social Medicine, University of Bristol, UK.
Lancet (London, England)
|November 30, 1996
概括
低出生体重会增加冠状动脉疾病的风险,特别是在体重指数 (BMI) 高的成年人中. 这突显了早期和成年期暴露对心血管健康的综合影响.
科学领域:
- 心血管流行病学心血管流行病学
- 健康和疾病的发育起源 (DOHaD)
背景情况:
- 胎儿发育 (出生体重) 与晚期冠心病 (CHD) 风险之间确立的联系.
- 研究了这种关联是否源于早期暴露或早期生活和成人因素之间的相互作用.
研究的目的:
- 确定出生体重和成人因素在预测冠心病中的相互作用.
- 评估生命早期暴露与生命早期和成年期综合影响对心脏病风险的作用.
主要方法:
- 在南威尔士州凯尔菲利的1258名45-59岁男性的前性研究中,使用了出生体重数据.
- 收集了10年来关于健康行为,心脏病发病率和风险因素的数据.
- 结果指标:致命和非致命的冠状动脉心脏病.
主要成果:
- 较高的出生体重与较低的冠状动脉心脏病风险相关 (p=0.03).
- 发现出生体重和体重指数 (BMI) (p=0.048调整) 之间存在显著的相互作用.
- 出生体重和心脏病风险之间的反向关联仅限于最高BMI的男性.
结论:
- 出生体重与心血管疾病的相关性并非由社会经济地位或传统的成人风险因素来解释.
- 出生体重和成人BMI之间的相互作用表明,低出生体重对高BMI的个体构成更高的心脏病风险.
- 冠状动脉疾病风险似乎是由早期和晚年暴露的累积影响所塑造的.
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