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在血清丸激素水平低的男性中,隐性前列腺癌
A Morgentaler1, C O Bruning, W C DeWolf
1Division of Urology, Beth Israel Hospital, Harvard Medical School, Boston, Mass. 02215, USA.
JAMA
|December 18, 1996
概括
低丸激素水平的男性患上隐性前列腺癌的患病率很高,即使有正常的查测试. 这表明标准查可能会错过这些人的癌症.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 低血清丸激素在老年男性中很常见.
- 低丸激素和前列腺癌检测之间的关系尚未完全理解.
- 标准的前列腺癌查可能在患有阴性腺的男性中效果不佳.
研究的目的:
- 为了研究总体或自由丸激素低的男性前列腺癌的患病率.
- 在这个人群中评估标准查方法 (PSA,DRE) 的有效性.
主要方法:
- 对77名男性进行回顾性分析,他们丸激素低,数字直肠检查 (DRE) 正常,前列腺特异抗原 (PSA) ≤4.0 ng/mL.
- 所有的男性都接受了超声波导向的前列腺阴影针活检.
- 收集的数据包括PSA,PSA密度,前列腺体积和水平.
主要成果:
- 前列腺癌在所有男性中被检测到14%,在60岁或以上的男性中被检测到29%.
- 对于所有检测到的癌症,格里森得分为6或7.
- 在癌症和良性群体之间没有发现PSA,PSA密度,前列腺体积或丸激素水平的显著差异.
结论:
- 活检可检测的前列腺癌的显著患病率存在于男性低丸激素,尽管正常的PSA和DRE.
- 数字直肠检查和PSA水平似乎是低丸激素男性前列腺癌的不敏感指标.
- 血清中的雄激素水平可能会影响前列腺特异性抗原水平,可能掩盖癌症检测.
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