一项基于人口的研究,研究神经母细胞瘤查的有用性
W G Woods1, M Tuchman, L L Robison
1University of Minnesota, Minneapolis, USA.
Lancet (London, England)
|December 21, 1996
概括
在婴儿中进行神经母细胞瘤大规模查可以提高检测率,但不能减少老年儿童中晚期疾病的发生率. 这表明婴儿查不太可能降低神经母细胞瘤总体死亡率.
科学领域:
- 儿科瘤学 儿科瘤学
- 公共卫生查计划 公共卫生查计划
- 癌症流行病学 癌症流行病学
背景情况:
- 在症状出现之前检测神经母细胞瘤可能会改善结果.
- 北克神经母细胞瘤查项目旨在评估大规模查是否可以降低婴儿死亡率.
- 这项研究报告了查对1岁以上儿童预后不良的神经母细胞瘤发病率的影响.
研究的目的:
- 为了确定婴儿神经母细胞瘤的大规模查是否会降低死亡率.
- 评估查对1岁以上儿童中晚期神经母细胞瘤发病率的影响.
主要方法:
- 北克的婴儿 (n=476,603) 在3周和6个月时接受了尿中甲基荷兰胺测试.
- 阳性查导致评估和治疗.
- 标准化发病率 (SIR) 是通过比较北克州与明尼苏达州和安大略省来计算的.
主要成果:
- 查遵守率很高 (91%在3周,74%在6个月).
- 诊断了118例神经母细胞瘤病例;43例临床前,20例临床前3周,55例临床后3周.
- 北克显示发生率显著增加 (SIR 2.17),特别是在1岁以下的婴儿 (SIR 2.85),老年儿童的晚期疾病没有减少.
结论:
- 婴儿神经母细胞瘤查增加了诊断的发病率,但没有减少老年儿童不良的晚期疾病.
- 目前的婴儿查方案不太可能降低与神经母细胞瘤相关的死亡率.
- 可能需要进一步的研究来确定更有效的查策略.
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