巨细胞,光滑肌肉细胞和组织因素在不稳定的心痛. 在急性冠状动脉综合征中对细胞介导血栓发生性的影响
P R Moreno1, V H Bernardi, J López-Cuéllar
1Cardiac Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA. prmoreno@bics.bwh.harvard.edu
Circulation
|December 15, 1996
概括
与血栓相关的组织因子,在不稳定的胸痛患者中较高. 这一因素与巨细胞和光滑肌细胞有显著的相关性,表明急性冠状动脉综合征中细胞驱动的血栓形成.
科学领域:
- 心血管病理学心血管病理学
- 血栓形成的研究研究.
- 细胞生物学 细胞生物学
背景情况:
- 组织因子 (TF) 的巨体表达与冠状动脉血栓性有关,特别是斑块破裂.
- 在没有斑块破裂的情况下,光滑肌肉细胞可以作为血栓生成基质.
- 识别TF的细胞相关性对于理解不稳定性胸痛至关重要.
研究的目的:
- 在不稳定性心痛中研究组织因子表达的细胞基础.
- 确定冠状动脉中组织因子和细胞成分之间的关系.
- 为了比较不稳定的心痛与稳定的心痛中的细胞发现.
主要方法:
- 分析了50例来自不稳定性胸痛患者的冠心样本和15例来自稳定性胸痛患者的冠心样本.
- 总面积和细分面积的三色染色.
- 免疫覆盖以识别巨细胞,光滑肌细胞和组织因子.
主要成果:
- 组织因子含量在不稳定性胸痛中 (42%) 与稳定性胸痛 (18%) 相比显著更高.
- 巨细胞含量也在不稳定性胸痛 (16%) 和稳定性胸痛 (5%) 中升高.
- 冠状动脉组织因子与巨细胞和平滑肌肉细胞区域在不稳定的心痛中显著相关 (r=0.83).
结论:
- 不稳定性心痛中组织因子含量增加与巨细胞和光滑肌肉细胞有关.
- 研究结果表明,急性冠状动脉综合征中血栓发生的细胞介导机制.
- 细胞组成在不稳定的心痛中对冠状动脉的血栓潜力起着关键作用.
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