雌激素替代疗法对绝经后妇女的氨酸- ангиотензин系统的影响
H Schunkert1, A H Danser, H W Hense
1Klinik und Poliklinik für Innere Medizin II, University of Regensburg, Germany.
Circulation
|January 7, 1997
概括
雌激素替代疗法 (ERT) 增加了血管激素,但抑制了氨酸,这是氨酸-血管激素系统中的关键激素. 这一发现对于患有心血管疾病的绝经后妇女至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 心血管生理学心血管生理学
- 生殖医学 生殖医学
背景情况:
- 已知口服雌激素替代疗法 (ERT) 可以增加血管素合成.
- 对于ERT对氨酸,ACE和阿尔多斯特的影响仍然不太清楚.
- 了解这些影响对于患有心力衰竭,冠状动脉疾病或高血压的绝经后妇女至关重要.
研究的目的:
- 为了研究雌激素替代疗法对氨酸 - 血管新生素系统的组成部分的影响.
- 为了比较经更年期妇女与没有ERT,以及年龄相匹配的男性的宁,血管酶原,ACE活性和阿尔多斯水平.
主要方法:
- 使用免疫放射测试测量素的量化.
- 通过使用标准测定来确定阿尔多斯特,血管激素和ACE活性.
- 对绝经后妇女和年龄相匹配的男性以人口为基础的样本进行分析.
主要成果:
- 与没有ERT的女性和男性相比,接受ERT的女性表现出明显较低的蛋白水平.
- 与没有ERT和男性相比,接受ERT的女性的血管素水平显著更高.
- 口服和透皮ERT都发生了宁抑制,而血管新生素的增加是口服ERT的特征.
结论:
- 雌激素替代疗法与显著的宁抑制有关,独立于年龄,BMI或血压.
- 通过ERT诱导血管新生素已经得到了充分的证据,但由于测量方法,氨酸抑制可能被忽视了.
- 这些荷尔蒙变化需要在有心血管风险因素的绝经后妇女考虑.
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