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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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克隆一个分解金属蛋白酶,处理前体瘤-亡因子-α的克隆

M L Moss1, S L Jin, M E Milla

  • 1Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc., Research Triangle Park, North Carolina 27709, USA.

Nature
|February 20, 1997
PubMed
概括

瘤坏死因子-α (TNF-α) 是炎症中的一个关键细胞因子. 研究人员净化和克隆了TNF-α转化酶 (TACE),一种金属蛋白酶,这对于产生成熟的TNF-alpha至关重要.

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Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...