对女性肺栓塞风险因素的前性研究
S Z Goldhaber1, F Grodstein, M J Stampfer
1Channing Laboratory, Boston, Mass, USA. szgoldhabe@bics.bwh.harvard.edu
JAMA
|February 26, 1997
概括
肥胖,吸烟和高血压是女性肺栓塞 (PE) 的重要危险因素. 管理这些因素可以降低PE和冠心病的风险.
科学领域:
- 心血管科学 心血管科学
- 流行病学 流行病学
- 妇女健康 妇女健康
背景情况:
- 肺栓塞 (PE) 是一种严重的疾病,具有几个已知的危险因素.
- 鉴定女性可修改的风险因素对于预防策略至关重要.
研究的目的:
- 研究生活方式和生理因素之间的关联以及女性患肺栓塞的风险.
主要方法:
- 一项前性研究涉及112,822名年龄在30-55岁的女性,持续16年 (1976-1992年).
- 通过每两年一次的关于体重,吸烟,高血压,糖尿病和高胆固醇血症的问卷收集的数据.
- 记录了280例肺栓塞病例,其中125例被归类为初级PE.
主要成果:
- 肥胖 (BMI ≥29.0 kg/m2) 独立地与近三倍的初级PE风险增加有关 (RR=2.9).
- 严重吸烟 (每天≥35支烟) 显著增加了初级PE风险 (RR=3.3).
- 高血压也独立预测了增加的初级PE风险 (RR=1.9),即使在调整了BMI之后.
结论:
- 肥胖,吸烟和高血压是女性肺栓塞的关键独立危险因素.
- 控制这些可修改的风险因素可能会减少PE的发生率.
- 这些干预措施也可以降低冠心病的风险.
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