一个Polycomb组基因调节了Arabidopsis中的同源基因表达
J Goodrich1, P Puangsomlee, M Martin
1John Innes Centre for Plant Science Research, Norwich, UK.
Nature
|March 6, 1997
概括
阿拉比多普西斯中的CURLY LEAF基因通过稳定抑制花同源基因,对维持细胞命运至关重要. 这个基因,这个基因.
科学领域:
- 植物分子生物学 植物分子生物学
- 发育生物学是发展生物学.
- 遗传学 是一个遗传学.
背景情况:
- 细胞命运的决定依赖于通过细胞分裂稳定地继承基因活动状态.
- 在Drosophila中,Polycomb组和trithorax组基因维持这些状态以确定命运.
- 类似基因组在植物细胞命运决定中的作用尚未完全理解.
研究的目的:
- 为了调查CURLY LEAF (CLF) 基因在Arabidopsis thaliana中的作用.
- 为了确定CLF在维持细胞命运方面是否与Polycomb组基因具有类似的功能.
- 探索植物和动物之间的细胞命运的基因调节机制的保护.
主要方法:
- 在Arabidopsis.中对CURLY LEAF基因的遗传分析.
- 关于CLF基因产物的分子表征.
- 对CLF蛋白同质性与已知Polycomb组蛋白质的比较分析.
主要成果:
- 这种CURLY LEAF基因对于在Arabidopsis中稳定抑制花同源基因至关重要.
- 该CLF基因编码的蛋白质是同类的增强器的胃,一个Polycomb-组基因产物.
- 这种同质性表明,在维持基因表达状态方面,存在一种保留的功能.
结论:
- 在植物细胞命运的决定中,CURLY LEAF基因通过确保稳定的基因沉默起到至关重要的作用.
- 多组组基因可能在细胞命运确定中具有保留的功能,跨越包括植物和动物在内的各个王国.
- 这一发现突显出一种共同的分子机制,用于维持不同生物体的发育稳定性.
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