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在Ras转化纤维细胞中由氧化剂介导的线粒体信号传递

K Irani1, Y Xia, J L Zweier

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Science (New York, N.Y.)
|March 14, 1997
PubMed
概括

构成性活跃的H-RasV12转化细胞,增加像超氧化物这样的反应性氧物种 (ROS). 针对Ras通路,黄蛋白和Rac1的抗氧化剂和抑制剂抑制了ROS和细胞生长,表明ROS在Ras诱导的转化中介.

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