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相关实验视频

在左心室卸载期间的 Septal 功能.

M R Moon1, A F Bolger, A DeAnda

  • 1Department of Cardiovascular and Thoracic Surgery, Stanford (Calif) University School of Medicine 94305, USA.

Circulation
|March 4, 1997
PubMed
概括
此摘要是机器生成的。

左心室卸载会对隔膜功能产生负面影响. 这种减少隔膜缩和输出可能会在机械左心室支期间恶化右心室收缩性.

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科学领域:

  • 心脏病学 心脏病学
  • 心血管生理学心血管生理学
  • 生物医学工程 生物医学工程

背景情况:

  • 已知左心室 (LV) 的机械循环支持会改变心室几何形状,并降低右心室 (RV) 功能.
  • 在此之前,还没有研究 LV 卸载对心室间隔膜的缩功能的具体影响.

研究的目的:

  • 为了研究 LV 体积和压力卸载对腹腔间隔膜几何形状和缩功能的影响.

主要方法:

  • 七只开放胸部麻醉的狗通过紧左心房压力来进行LV预负荷减轻.
  • 使用压力控制伺服机制从左心室抽取血液,减少LV预负载.
  • 两维心声图被用来评估隔膜的几何和功能.

主要成果:

  • LV 卸载显著降低了 LV 压力和终端腹痛横截面积.
  • 腹腔间隔膜向右心室移动,平坦化,并且其末端腹筋厚度增加.
  • 缩性隔膜厚度和隔膜输出显著下降,表明缩功能受损.

结论:

  • 左心室的卸载改变了心室间隔膜的几何结构.
  • LV卸载可以减少隔膜缩的加厚和输出.
  • 这些隔膜变化可能会导致机械LV支期间的RV收缩能力受损.