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组织因子抗原和人类冠状动脉样硬化斑块中的活性
D Ardissino1, P A Merlini, R Ariëns
1Division of Cardiology, IRCCS Policlinico San Matteo, Pavia, Italy. ARDIS001@planet.it
Lancet (London, England)
|March 15, 1997
概括
冠状动脉斑块中较高的组织因子水平与不稳定的心痛和心肌梗塞中血栓形成风险增加相关. 这表明组织因子.
科学领域:
- 心血管研究研究心血管研究
- 血栓形成生物学 血栓形成生物学
- 动脉样硬化病原体的产生
背景情况:
- 冠状动脉样硬化斑块破裂是急性冠状动脉综合征的关键阶段.
- 然而,并非所有破裂的斑块都会导致血栓形成,这表明其他因素也会导致血栓形成.
- 了解这些因素对于管理不稳定的心痛和心肌梗塞至关重要.
研究的目的:
- 调查组织因子在冠状动脉斑块破裂的血栓反应中的作用.
- 为了比较患有稳定性胸痛,不稳定性胸痛和心肌梗塞的患者的组织因子水平.
主要方法:
- 从50名冠状动脉疾病患者中采集了动脉切除样本.
- 在这些样本中测量了组织因子抗原和活性.
- 患者被分为稳定性胸痛,不稳定性胸痛和心肌梗塞组.
主要成果:
- 与稳定性胸痛相比,患有不稳定性胸痛和心肌梗塞的患者中,组织因子抗原和活性的中位数显著更高.
- 具体而言,抗原水平为66.1 pg/mg与32.4 pg/mg (p=0.0001) 相比,活性水平为0.22 mU/mg与0.13 mU/mg (p=0.0004).
结论:
- 组织因子是凝血级联的关键发起者,可以解释冠状动脉斑块破裂后观察到的不同血栓反应.
- 动脉硬性斑块中的组织因子升高与急性冠状动脉综合征中血栓形成的风险更高有关.
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