相关实验视频
Updated: Jul 28, 2026

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Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
Published on: April 4, 2012
在背脊髓损伤后,体感皮层的停活和重新激活
N Jain1, K C Catania, J H Kaas
1Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA.
Nature
|April 3, 1997
概括
背脊柱对于将感官信息传输到大脑体感官皮层至关重要. 这些通路的损伤会导致大脑过程如何接触的显著,持久的变化,没有其他脊柱通路可以补偿.
科学领域:
- 神经科学是一个神经科学.
- 身体感官系统研究 研究体感官系统研究
背景情况:
- 脊髓的背脊柱传统上被认为是大脑体感信息的主要通道.
- 脊柱病变的功能影响一直在争论中,报告的后果各不相同.
研究的目的:
- 调查背脊柱 afferents 的必要性,以激活主要体感皮层 (区域3b).
- 为了检查背脊柱损伤对皮质可塑性和感官重绘的影响.
主要方法:
- 在动物模型中,宫背柱切割 (完全和部分).
- 在对侧原体感官皮层 (区域3b) 记录神经元对手部刺激的反应.
- 在长时间 (几周到几个月) 评估功能恢复和感官重新映射.
主要成果:
- 完整的背脊切割立即取消了区域3b神经元对手部刺激的反应.
- 部分切割导致皮质表现的扩展,以随着时间的推移为剩余的附属物.
- 经过长时间的恢复后,3b区域的剥夺的手表达变得对面部输入有反应.
结论:
- 主体体感官皮层的3b区域对于正常功能至关依赖背脊柱输入.
- 其他脊髓通道在受伤后不能有效地替代背脊柱.
- 脊柱损伤后会出现显著的皮层重组,但这并不能恢复受影响身体部位的正常感官处理.
相关概念视频
Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Motor and Sensory Areas of the Cortex
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Overview of Somatic Sensory Pathways
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Major Somatic Sensory Pathways
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
Somatic Spinal Reflexes
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
Somatosensory, Motor, and Association Cortex
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...

