在临床局部化前列腺癌患者的长期生存的基于人口的研究
1Health Care Financing Administration, Office of Research and Demonstrations, Baltimore, MD 21244-1850, USA.
Lancet (London, England)
|March 29, 1997
概括
这项研究表明,局部性前列腺癌的生存率因等级和治疗而异. 高度瘤 (3级) 是侵略性的,以前的研究可能高估了前列腺切除术的益处.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 公共卫生 公共卫生
背景情况:
- 关于局部性前列腺癌治疗结果的有限的公正数据存在.
- 现有的数据往往来自小型,专业的中心,具有潜在的分期偏差.
- 需要大规模的基于人口的数据来准确评估生存率.
研究的目的:
- 确定局部性前列腺癌的整体和前列腺癌特异性生存率.
- 为了比较前列腺切除术,放射治疗和保守管理的生存结果.
- 为了解决前期前列腺癌结局研究中的数据限制和偏见.
主要方法:
- 对59,876名年龄在50-79岁之间的癌症登记病人的分析.
- 使用治疗意图和接受治疗的方法检查治疗效应.
- 卡普兰-梅尔估计生存率的方法.
主要成果:
- 10年生存率因癌症等级和治疗方式而异.
- 第三级前列腺癌在所有治疗组中都表现出高度的攻击性.
- 治疗意图和接受治疗的分析显示出差异,特别是前列腺切除术的结果.
结论:
- 这些发现挑战了先前对局部性前列腺癌治疗的生存率估计.
- 在使用接受治疗方法的研究中,激进前列腺切除术的好处可能被高估了.
- 3级前列腺瘤需要积极的管理,因为它们固有的侵略性.
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