估计中心大动脉压力波形通过数学的转换的辐射计压力. 一般化转移函数的验证
1Department of Internal Medicine, Johns Hopkins University Medical Institutions, Baltimore, Md, USA.
Circulation
|April 1, 1997
概括
中央大动脉压力可以通过使用通用转移函数 (TF) 来通过辐射动脉测量进行非侵入性估计. 这种方法提供了准确的动脉合规性估计,是心血管评估的宝贵工具.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 血液动力学 血液动力学
背景情况:
- 中央大动脉压力是心血管状况的关键指标,但需要进行侵入性测量.
- 外围压力提供了一个非侵入性的替代方案,尽管它们与中心压力不同.
- 数学转换可以从外围测量中近似中央压力.
研究的目的:
- 为了测试转换外围压力的有效性,以近似中央大动脉压力.
- 检查这些转换中的跨主体和内主体变异性.
- 为了评估单个,平均的转换的适用性.
主要方法:
- 在20名患者中测量了侵入性中央大动脉和非侵入性辐射压力.
- 使用参数模型计算压力之间的转移函数 (TF).
- 单个TF的平均值是为了创建一个通用的TF.
主要成果:
- TFs在幅度 (24.9%) 和频率 (16.9%) 中表现出患者间的变化.
- 患者内TF变异发生在血动力学过渡期间的28.5%患者中.
- 一般化的TF准确地估计了中心压力 (误差<3.8mm Hg) 和动脉合规性 (准确率为6%).
结论:
- 中枢大动脉压力可以准确地估计从辐射度使用一个通用TF.
- 重建的波形有助于估计动脉合规性.
- 由于波形忠实性要求,增强指数可能被低估.
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