诱导道聚类由寡头质细胞
M R Kaplan1, A Meyer-Franke, S Lambert
1Stanford University School of Medicine, Department of Neurobiology, California 94305, USA.
Nature
|April 17, 1997
概括
氧基细胞对于沿中央神经系统轴突聚集通道至关重要,形成Ranvier的节点. 这一过程对于神经冲动传导至关重要,由寡细胞分泌的蛋白质诱导.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 轴轴运输 轴轴运输 轴轴运输 轴轴运输
背景情况:
- 在中枢神经系统 (中枢神经系统) 中,寡二细胞化轴突,导致通道分离成Ranvier的节点.
- 驱动这些节点的规律间距的机制尚未完全理解,质接触或轴突细胞骨的潜在作用.
- 施万细胞和星球细胞已涉及到分别在外周和中枢神经系统轴突中的通道聚类.
研究的目的:
- 调查细胞在中枢神经系统轴突沿线通道的聚类和间距中的作用.
- 为了确定基细胞接触或分泌因素是否负责诱导道聚类.
- 阐明寡细胞在形成轴突道集群中的体内相关性.
主要方法:
- 在培养中利用纯化的老鼠视网膜质细胞来研究寡细胞-轴突相互作用.
- 研究了寡类细胞分泌的蛋白质对通道聚类的影响.
- 在突变大鼠中检查了缺少寡细胞的轴突盐道分布.
主要成果:
- 在体外和体外模型中发现,基细胞对于道聚类是必要的.
- 一种分泌的寡细胞蛋白被确定为诱导,但不是维持通道聚类的关键.
- 定期间隔的通道集群在预测的间隔内形成,即使没有直接的质-轴突接触.
- 缺少寡头细胞的老鼠显著减少了轴突管集群.
结论:
- 寡类细胞在诱导中枢神经系统轴突沿线通道聚类方面发挥着至关重要的作用.
- 寡头细胞分泌的因子是通道聚类的关键媒介,独立于细胞间间距的直接细胞接触.
- 这些发现凸显了寡细胞在建立髓化轴突的功能架构方面的重要性.
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