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Published on: March 2, 2020
在汗水和多抗性Staphylococcus epidermidis中排泄西普罗素
1Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Denmark.
Lancet (London, England)
|January 18, 1997
概括
汗水中的西普洛克萨分泌迅速驱动斯塔菲洛科克斯表皮杆菌的耐药性,即使在健康个体中也是如此. 这种抗生素耐药性在皮肤细菌中迅速发展,在治疗结束后持续很长时间.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 斯塔菲洛科克斯表皮菌表现出对西普罗夫洛克萨的快速耐药性发展.
- 齐普罗夫洛克萨通过人类汗水分泌,可能有助于抗药性.
- 这项研究研究了S. epidermidis在西普罗夫洛克萨治疗后的下巴和鼻腔菌群中耐药性的发展.
研究的目的:
- 评估健康个体的下巴和鼻腔植物中的S. epidermidis对西普罗夫洛克萨辛耐药性的发展.
- 为了将汗水中的西普罗撒辛度与抗药性发展相关联.
- 为了确定治疗后耐药菌株的持久性.
主要方法:
- 7名志愿者接受了口服西普罗夫洛克萨 (750毫克每天两次,持续7天).
- 测量了汗水中的西普罗夫洛克萨辛度.
- 在治疗期间和治疗后监测下和鼻孔中的S. epidermidis耐药性.
- 对S. epidermidis的基因定型是使用限制片段长度多态化进行的.
主要成果:
- 在治疗期间,汗液中的西普罗撒度增加,达到5.5微克/毫升.
- 在所有参与者中检测到抗西普罗素的S. epidermidis菌株 (中级和高级).
- 抗药性迅速发展在上S. epidermidis (平均2.7天) 和鼻上S. epidermidis (平均11天).
- 耐药菌株在治疗后的37-39天内持续存在.
结论:
- 在S. epidermidis中,快速发展的西普洛素耐药性与汗水中的药物分泌有关.
- 这种现象可能会导致临床和社区环境中出现多药耐药细菌.
- 高度使用西普洛素可能会加剧皮肤菌群抗生素耐药性的问题.
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