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Updated: Aug 7, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
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塔莫西芬降低胆固醇7倍,并废除了在非脂蛋白E淘汰赛小鼠的脂质病变的发展

J Reckless1, J C Metcalfe, D J Grainger

  • 1Department of Biochemistry, University of Cambridge, UK. jr3@mole.bio.cam.ac.uk

Circulation
|March 18, 1997
PubMed
概括

塔莫西芬 (TMX) 治疗显著减少了阿波利波蛋白E (apo E) 淘汰赛小鼠的脂质病变,降低了胆固醇和甘油三. 这表明TMX可能通过改变脂蛋白样本和增加TGF-β来提供心血管保护.

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